科研之友
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摘要
We report herein a method based on a radical-ionic sequence between an allylic alcohol and an a-iodo acid in the presence of substoichiometric amounts of lauroyl peroxide (DLP) to produce an atom transfer radical addition (ATRA) adduct, which subseqently underwent an acid-mediated lactonization. This approach can be described as a free radical reaction followed by an intermolecular iodolactonization. Twenty-two experiments were carried out to evaluate the scope of the reaction, which afforded a wide variety of iodo lactones with diverse functionalities. The utility of this approach was demonstrated in the synthesis of the natural product (-)-de-O-methylcentrolobine.
- 出版日期2016-3
