Sparstolonin B attenuates spinal cord injury-induced inflammation in rats by modulating TLR4-trafficking

作者：Yuan, Jianjun; Zhang, Xueli^*; Zhu, Rusen; Cui, Zijian; Hu, Wei

来源：Molecular Medicine Reports, 2018, 17(4): 6016-6022.

DOI：10.3892/mmr.2018.8561

• sparstolonin B
• spinal cord injury
• inflammation
• Toll-like receptor 4

The present study used a spinal cord injury (SCI) model to evaluate whether sparstolonin B was able to prevent SCI, and to investigate the underlying signaling mechanism. Sparstolonin B attenuated the SCI-induced Batto, Beattie and Bresnahan score and water content in rats. Sparstolonin B attenuated the mRNA expression of proinflammatory cytokines interleukin (IL)-18, IL-6, IL-1, and IL-23, decreased the levels of tumor necrosis factor- and interferon-, and decreased caspase-3 activity and apoptosis regulator Bax protein expression in SCI rats. Similarly, sparstolonin B inhibited monocyte chemoattractant protein-1 mRNA levels, and Toll-like receptor (TLR) 4, myeloid differentiation primary response protein MyD88 (MyD88) and nuclear factor (NF)-B protein levels in SCI rats. The present results suggested that sparstolonin B may attenuate SCI-induced inflammation and apoptosis in rats by modulating the TLR4/MyD88/NF-B signaling pathway.

• 出版日期2018-4
• 单位天津市人民医院