Allergic Mechanisms in Eosinophilic Esophagitis

作者：Wechsler Joshua B; Bryce Paul J^*

来源：Gastroenterology Clinics of North America, 2014, 43(2): 281-+.

DOI：10.1016/j.gtc.2014.02.006

• Eosinophilic esophagitis
• Allergic mechanism
• Atopic
• Antigen sensitization
• T-helper lymphocyte type 2 immunity
• Pathogenesis

Eosinophilic esophagitis is rapidly increasing in incidence. It is associated with food antigen-triggered, eosinophil-predominant inflammation, and the pathogenic mechanisms have many similarities to other chronic atopic diseases. Studies in animal models and from patients have suggested that allergic sensitization leads to food-specific IgE and T-helper lymphocyte type 2 cells, both of which seem to contribute to the pathogenesis along with basophils, mast cells, and antigen-presenting cells. In this review our current understandings of the allergic mechanisms that drive eosinophilicesophagitis are outlined, drawing from clinical and translational studies in humans as well as experimental animal models.

• 出版日期2014-6
• 单位西北大学