Disk-like micelles with cylindrical pores from amphiphilic polypeptide block copolymers

作者：Lin, Xue; He, Xiaohua^*; Hu, Chaoqun; Chen, Yuxiang; Mai, Yiyong^*; Lin, Shaoliang^*

来源：Polymer Chemistry, 2016, 7(16): 2815-2820.

DOI：10.1039/c6py00152a

• DIBLOCK COPOLYMERS
• TRIBLOCK COPOLYMER
• VESICLES
• MORPHOLOGIES
• POLYMER
• FILMS
• ASSEMBLIES
• BEHAVIOR
• WATER
• NCA

An unprecedented two-dimensional (2D) disk-like micelle with cylindrical pores was achieved for the first time by self-assembly of the amphiphilic block copolypeptide poly(ethylene glycol)-block-poly(.-benzylL- glutamate) (PEG-b-PBLG) in solution. The aggregate structures were fully characterized by TEM, SEM, H-1 NMR, AFM and CD. The research results showed that the a-helical conformation of PBLG blocks plays a key role in the formation process of a disk-like morphology. By tuning the ratio between the hydrophilic block and hydrophobic block in PEG-b-PBLG copolymers, various aggregate structures including micelles, disk-like micelles, vesicles and large vesicles can be achieved. The research results are helpful to expand the self-assembly fields and can provide more nanostructural materials.

• 出版日期2016
• 单位上海交通大学; 华东理工大学; 华东师范大学