A Paradigm Shift: The New Novel Oral Anticoagulation Agents

作者：Saeed Wajeeha; Burke James F; Mirrani Ghazi; Sirinivasa Minisha; Nabi Usman; Hayat Umar; Khan Zubair; Sardar Muhammad Rizwan^*

来源：Journal of the College of Physicians and Surgeons Pakistan, 2016, 26(7): 611-619.

• Atrial fibrillation
• Stroke
• Coumadin
• New oral anticoagulation agents
• International Normalized Ratio (INR)

Atrial fibrillation (AF) is the most common arrhythmia and represents one-third of the arrhythmia-related hospital admissions in the developed countries. Embolic strokes associated with AF are more severe and disabling. Thromboembolic stroke prevention is a major goal in treatment of AF and Warfarin has successfully served this purpose for many years. Drug-drug interaction and regular monitoring with Warfarin pose a significant challenge where health care system has limited resources; and lack of a well-structured health system, hinders regular International Normalized Ratio (INR) monitoring. Novel oral anticoagulants (NOACs) have opened up a new exciting chapter in the field of anticoagulation in non-valvular atrial fibrillation (NVAF). This review discussed the landmark trials that led to the development of NOACs and explored the potentials of these new agents with simultaneous comparison of Warfarin.

• 出版日期2016-7