Age-dependent decreases of high energy phosphates in cerebral gray matter of patients with bipolar I disorder: A preliminary phosphorus-31 magnetic resonance spectroscopic imaging study

作者：Dudley Jonathan A^*; Lee Jing Huei; Durling Michelle; Strakowski Stephen M; Eliassen James C

来源：Journal of Affective Disorders, 2015, 175: 251-255.

DOI：10.1016/j.jad.2015.01.026

• Bipolar disorder
• Bioenergetics
• P-31 MRS

Objectives: To identify abnormalities in high energy phosphate cerebral metabolism in euthymic bipolar disorder.
Methods: Phosphorus-31 magnetic resonance spectroscopic imaging (P-31 MRSI) data were acquired from the entire brain of 9 euthymic adults with bipolar disorder and 13 healthy adults. Estimates of phosphocreatine (PCr) and adenosine triphosphate (ATP) in homogeneous gray and white matter were obtained by tissue regression analysis.
Results: Analyses of covariance revealed the effect of age to be significantly different between bipolar and healthy groups for concentrations of PCr (p=0.0018) and ATP (p=0.013) in gray matter. These metabolites were negatively correlated with age in gray matter in bipolar subjects while PCr was positively correlated with age in gray matter of healthy subjects. Additionally, age -corrected concentrations of PCr in gray matter vvere significantly elevated in bipolar subjects (p=0.0048).
Limitations: Given Lha L this cross-sectional study possessed a small sample and potentially confounding effects of medication status, we recommend a larger, longitudinal study to more robustly study I elationships between bioenergetic impairment and duration of disease.
Conclusions: Our results suggest bioenergetic impairment related to mitochondrial function may be progressive in multi-episode bipolar subjects as they age.

• 出版日期2015-4-1