Acid-triggered release of doxorubicin from a hydrazone-linked Gd3+-texaphyrin conjugate

作者:Lee Min Hee; Kim Eun Joong; Lee Hyunseung; Park Sun Young; Hong Kwan Soo; Kim Jong Seung; Sessler Jonathan L
来源:Chemical Communications, 2016, 52(69): 10551-10554.
DOI:10.1039/c6cc05673c

摘要

The hydrazone-based Gd3+-texaphyrin doxorubicin conjugate 1, releases active doxorubicin at acidic pH values, allowing its components to be followed by two complementary imaging methods, namely Off-On fluorescence enhancement and MR imaging. It thus acts as a promising theranostic agent.

  • 出版日期2016