Comparison of Telbivudine and Entecavir Therapy on Nephritic Function and Drug Resistance in Patients with Hepatitis B Virus-Related Compensated Cirrhosis

作者：Shen, Huajiang; Ding, Feng; Wang, Zhiwei; Sun, Fang; Yu, Yafeng; Zhou, Jiankang; Xu, Wenfang; Ni, Jianchao; Wang, Jiangang; Yang, Yida^*

来源：Cellular Physiology and Biochemistry, 2016, 40(1-2): 370-378.

DOI：10.1159/000452552

• HBV-related compensated cirrhosis
• Nephritic function
• ETV
• LDT
• eGFR

Background: To compare the impact of telbivudine (LDT) and entecavir (ETV) administration on nephritic function. Method: One hundred thirty patients diagnosed with hepatitis B virus (HBV)-related compensated cirrhosis were randomly divided into LDT (600 mg/d) or ETV (0.5 mg/d) groups. Results: The drug resistance rate was higher following LDT treatment compared to ETV treatment (16.9% vs. 1.5%, P=0.0006). The mean creatinine level decreased compared to baseline in the LDT group (0.81 vs. 0.94 mg/di, P=0.000). The change in median glomerular filtration rate (eGFR) compared to baseline in the LTD and ETV groups was 22.3 and -3.3, respectively, at 2 years (P=0.000). In patients with mild nephritic injury (eGFR< 90 ml/min/1.73m(2)), the median eGFR increased by 28.0 ml/min/1.73m(2) in the LDT group and decreased by 4.3 ml/min/1.73m(2) in the ETV group (p=0.000). The eGFR in 88.5% of patients (23/26) from the LDT group increased > 90 ml/min/1.73m(2). The percentage of patients with an eGFR > 90 ml/min/1.73m(2) increased from 60.0% to 92.3% in the LDT group and from 64.6% to 69.2% in the ETV group. Conclusion: In patients with HBV-related compensated cirrhosis. LDT treatment was more effective in protecting nephritic function and was associated with a higher drug resistance rate, but did not contribute to a better outcome compared with ETV treatment.

• 出版日期2016
• 单位浙江大学