Anemia, red blood cell transfusions, and necrotizing enterocolitis

作者：Maheshwari Akhil^*; Patel Ravi M; Christensen Robert D

来源：Seminars in Pediatric Surgery, 2018, 27(1): 47-51.

DOI：10.1053/j.sempedsurg.2017.11.009

• NEC
• Anemia
• Transfusion
• RBC
• Intestinal injury

In the past 15 years, multiple clinical studies have identified a temporal association between red blood cell (RBC) transfusions and necrotizing enterocolitis (NEC).With some variability, most of these studies indicate that up to one-third of all cases of NEC involving very low-birth weight infants may occur within 24-48 h after receiving a RBC transfusion. There is also evidence that the risk of such transfusion associated NEC may be higher in infants transfused with the greatest severity of anemia. In this article, we summarize the clinical evidence pertaining to these issues; specifically, the contribution of RBC transfusions, and the contribution of severity of underlying anemia, to the pathogenesis of a type of NEC potentially termed, "transfusion/anemia-associated NEC".

• 出版日期2018-2