科研之友
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摘要
A novel tropoloisoquinoline alkaloid, neotatarine (1), was isolated from the 95% ethanol extract of the rhizome parts of Acorus calamus L. The chemical structure was unambiguously elucidated by spectroscopic and single-crystal X-ray diffraction analysis. Neotatarine (1) exhibited significantly inhibitory activity against A(beta 25 - 35) induced PC12 cell death with 2, 4 and 8 lM comparing with the assay control (P < 0.01).
