Association of tumor necrosis factor polymorphisms with Guillain-Barre syndrome

作者：Zhang Jing; Dong Hui; Li Bin; Li Chun yan; Guo Li^*

来源：European Neurology, 2007, 58(1): 21-25.

DOI：10.1159/000102162

• Guillain-Barre syndrome
• tumor necrosis factor
• gene polymorphism

It has been reported that the tumor necrosis factor (TNF)alpha promoter polymorphism is associated with autoimmune disease and inflammatory disease. It has also been claimed that this polymorphism may affect TNF alpha expression. We investigated the TNF alpha - 308 polymorphism and TNF alpha levels in 79 unrelated Chinese patients with Guillain-Barre syndrome (GBS) and 78 healthy controls using PCR-RFLP and ELISA assay. Patients with GBS were divided into 2 subgroups, acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN), based on electrophysiological information. We found that the TNF alpha 2 allele was associated with increased risk of GBS (OR = 1.876, 95% CI = 1.144-3.075, p = 0.008), particularly for AMAN, the main subtype ( OR = 2.914, 95% CI = 1.412-6.015, p = 0.004), but there was no association between TNF alpha polymorphism and AIDP. We also found that carriers of the TNF alpha 2 allele had significantly higher TNF alpha 2 levels than TNF alpha 1 homozygotes (p < 0.05). These data indicate that TNF alpha promoter polymorphism is responsible for susceptibility to GBS, especially to AMAN. The TNF alpha 2 allele is associated with higher levels of TNF alpha.

• 出版日期2007
• 单位河北医科大学