Advanced Glycation End Products and Acute Myocardial Infarction

作者：Celec Peter^*; Burska Stella; Sebekova Katarina; Kalousova Marta; Zima Tomas; Murin Jan

来源：Medical Principles and Practice, 2010, 19(3): 244-246.

DOI：10.1159/000273081

• Advanced glycation end products
• Carbonyl stress
• Acute myocardial infarction

Objective: The aim of this study was to analyse the dynamics of advanced glycation end products (AGEs) after acute myocardial infarction (MI). Subjects and Methods: Blood samples were taken from 20 non-diabetic patients with acute MI on the 1st, 2nd, 3rd and 5th day after the onset of symptoms. Serum AGE levels were estimated spectrofluorometrically. Results: A marked decrease in the AGE-specific fluorescence was observed, especially between the 1st and the 2nd days after MI. Conclusion: The findings of this study tend to contradict the suggestion that AGEs are relatively stable markers of carbonyl stress. Although the reason for this is currently unknown, this observation may have implications for ongoing studies of AGEs in cardiovascular diseases.

• 出版日期2010