Novel RNA recognition motif domain in the cytoplasmic polyadenylation element binding protein 3

作者：Tsuda Kengo; Kuwasako Kanako; Nagata Takashi; Takahashi Mari; Kigawa Takanori; Kobayashi Naohiro; Guentert Peter; Shirouzu Mikako; Yokoyama Shigeyuki^*; Muto Yutaka

来源：Proteins: Structure, Function, and Genetics , 2014, 82(10): 2879-2886.

DOI：10.1002/prot.24651

• 3 %26apos
• -UTR
• CPEB3
• CPE
• GluR2
• Mrna
• RRM
• NMR
• structure

The family of cytoplasmic polyadenylation element binding proteins CPEB1, CPEB2, CPEB3, and CPEB4 binds to the 3%26apos;-untranslated region (3%26apos;-UTR) of mRNA, and plays significant roles in mRNA metabolism and translation regulation. They have a common domain organization, involving two consecutive RNA recognition motif (RRM) domains followed by a zinc finger domain in the C-terminal region. We solved the solution structure of the first RRM domain (RRM1) of human CPEB3, which revealed that CPEB3 RRM1 exhibits structural features distinct from those of the canonical RRM domain. Our structural data provide important information about the RNA binding ability of CPEB3 RRM1.

• 出版日期2014-10
• 单位RIKEN