Diagnostic performance of diffusion-weighted imaging for prostate cancer: Peripheral zone versus transition zone

作者：Lee Hakmin; Hwang Sung Il; Lee Hak Jong; Byun Seok Soo; Lee Sang Eun; Hong Sung Kyu^*

来源：PLos One, 2018, 13(6): e0199636.

DOI：10.1371/journal.pone.0199636

Objectives
Diffusion-weighted imaging (DWI) has been shown to be an important component of multiparametric magnetic resonance imaging (mpMRI). We compared performance of DWI for detection of prostate cancer (PCa) in peripheral zone (PZ) and transition zone (TZ) of prostate.
Materials and methods
We reviewed data of 460 subjects who underwent preoperative 3.0-Tesla mpMRI and subsequently radical prostatectomy. Level of suspicion for PCa was graded using 5-grade Likert-scale from DWI. Topographic analyses were performed for location of tumor foci at each surgical specimen. Among those with DWI grade >= III, we analyzed concordance rate on the location of radiologic and pathologic index lesions between DWI and surgical specimens.
Results
Among 460 patients, 351 (76.3%) patients showed suspicious DWI lesions (57.5% in PZ, 42.5% in TZ). Multivariates regression analyses revealed significant associations between high DWI grade and adverse pathologic outcomes including pathologic stage, Gleason score, tumor volume and extracapsular extension (all p < 0.05). Overall concordance rates between DWI and surgical specimen were 75.8%, significantly higher in PZ than TZ (82.2% vs. 67.1% p = 0.002). Such concordance rate showed a positive linear association with increase in DWI grading (p < 0.001). Among 109 patients with DWI grade I-II, 28 (25.7%) harbored high grade disease (pathologic Gleason score >= 4 + 3).
Conclusions
DWI detects tumors in PZ of prostate more accurately than those in TZ. Such accuracy of DWI was shown to be more evident with higher DWI grade. Meanwhile, a negative DWI did not guarantee absence of high grade PCa.

• 出版日期2018-6-22