Fabrication and characterization of glutathione-imprinted polymers on fibrous SiO2 microspheres with high specific surface

作者：Wang, Yufei; Zhou, Jingjing; Zhang, Baoliang; Tian, Lei; Ali, Zafar; Zhang, Qiuyu^*

来源：Chemical Engineering Journal, 2017, 327: 932-940.

DOI：10.1016/j.cej.2017.06.184

• Molecular recognition
• Glutathione
• Thermosensitivity
• Fibrous silica microspheres

The Glutathione (GSH)-imprinted thermosensitive SiO2 microspheres with high specific surface have been successfully fabricated via a precipitation copolymerization, in which functional monomers N-isopropyl acrylamide and methacrylic acid polymerize on the surface of fibrous SiO2 microspheres with N, N'-methylene bisacrylamide as cross-linking agent. Detailed characterization demonstrates that the SiO2 microspheres not only possess fiber sphere-shaped structure with the pores radially extending outwards from the center, but also have outstanding surface area (521 m(2)/g) and relatively narrow pore size distribution ranging from 15 to 100 nm. Owing to this fibrous structure, the saturation adsorption capacity of the GSH-molecular imprinted polymer (MIP) microspheres reach up to 85 mg/g within 2 h, which is much higher than other the MIPs that have been reported. In addition, these microspheres also display an excellent selective adsorption of GSH (IF = 3.22). These results revealed that the fibrous SiO2 microspheres could be expected as MIP carriers to separate and purify biomacromolecules.

• 出版日期2017-11-1
• 单位西北工业大学