Hourly differences in air pollution on the risk of asthma exacerbation

作者：Kim Jayeun; Kim Ho^*; Kweon Jung

来源：Environmental Pollution, 2015, 203: 15-21.

DOI：10.1016/j.envpol.2015.03.040

• Air pollution
• Asthma
• Case-crossover
• Effect modification
• Emergency department

We investigated the association between hourly differences in air pollution and asthma exacerbation in Korea using asthma-related emergency department data and verified seasonality and demographic modifiers with an hourly temporal resolution. We applied time-stratified case-crossover adjusted for weather and influenza; the lag was stratified as 1-6, 7-12, 13-18, 19-24, 25-48, and49-72 h. Odds ratios (95% confidence interval) per interquartile range increase were 1.05 (1.00-1.11) after 1-6 h for PM10-2.5 and 1.10(1.04-1.16) after 19-24 h for O-3. Effect size was 1.14(1.06-1.22) at a 1-6 h lag in spring for PM10-25, and 1.25 (1.03-1.51) at a 25-48 h lag in winter for O-3. O-3 effects were age- and low socio-economic status-modified at a 7-12 h lag [1.25 (1.04-1.51)]. Increased PM10-2.5 and 03 increased the risk of asthma exacerbation; the effect of PM10-2.5 was most immediate.

• 出版日期2015-8