科研之友
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摘要
A new lignan, utilisin (1), and a new alkaloid, echinoutilin (2), together with eleven known compounds 3-13 were isolated from the grains of Echinochloa utilis Ohwi & Yabuno. Their structures were identified through the analysis of spectroscopic data. The absolute configuration of 2 was determined by Mosher's method. These compounds were evaluated for alpha-glucosidase inhibitory activity. Among them, compounds 2, 3 and 6 exhibited considerable alpha-glucosidase inhibitory activity with IC50 values of 42.1 +/- 1.3, 58.9 +/- 3.7, and 40.9 +/- 1.1 mu M, respectively. The results indicate that the grains of E. utilis will be useful in the treatment of diabetes control agents.
- 出版日期2017-10
