Adenosine A(1) receptors contribute to mitochondria vulnerability to pro-oxidant stressors

作者：Alba Minelli^*; Silvia Grottelli; Lanfranco Corazzi; Ilaria Bellezza; Grazia Rambotti Maria; Carla Emiliani; Bertil Fredholm B

来源：Mitochondrion, 2010, 10(4): 369-379.

DOI：10.1016/j.mito.2010.03.004

• Adenosine A(1) receptor
• MPP+ cytotoxicity
• Primary neuron/glial mixed cultures
• Mitochondrial functions
• Uncoupled mitochondria

A(1) adenosine receptors are highly expressed in the central nervous system. Mitochondrial function is a major player in adenosine receptors-mediated effects. Here, by using mice with genetic deletion of the A(1) receptor, we addressed the existence of a relationship between mitochondria functions and adenosine A(1) receptor. Mitochondrial functions and effects of MPP+ in primary mixed cultures are influenced by the presence of the A(1) receptor, demonstrating, for the first time, the mitochondrial localization of the adenosine A(1) receptor and suggesting a role for this receptor as a mitochondria(vulnerability factor.

• 出版日期2010-6