N1-Arylation of 1,4-Benzodiazepine-2-ones with Diaryliodonium Salts

作者：Khan Raysa; Felix Robert; Kemmitt Paul D; Coles Simon J; Tizzard Graham J; Spencer John^*

来源：Synlett, 2018, 29(2): 193-198.

DOI：10.1055/s-0036-1590920

• benzodiazepines
• N-arylation
• iodonium salt
• privileged scaffold
• benzotriazepine

A library of N1-arylated 5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones has been synthesized starting with unsymmetrical diaryliodonium salts using aqueous ammonia as a base. This can also be applied to a similar 1,3,4-benzotriazepin-2-one derivative.

• 出版日期2018-1