Daunorubicin and doxorubicin inhibit the [C-11]choline accumulation in cancer cells

作者：Mikecz Pal^*; Marian Terez; Miklovicz Tuende; Galuska Laszlo; Krasznai Zoltan; Toth Agnes; Goda Katalin; Tron Lajos; Hernadi Zoltan; Krasznai Zoard T

来源：Applied Radiation and Isotopes, 2009, 67(10): 1806-1811.

DOI：10.1016/j.apradiso.2009.07.007

• Doxorubicin
• Daunorubicin
• [C-11]choline
• [F-18]FDG
• PET
• P-glycoprotein
• Cancer cells

we studied how very short (10-40 min) incubation with anthracycline derivatives modifies the accumulation of PET tumor-diagnostic radiotracers in cancer cells. The human ovarian A2780 and A2780AD, human B lymphoid JY, human epidermoid KB-3-1 and KB-V-1, and smooth muscle DDT1 MF-2 cells were pre-incubated with daunorubicin and doxorubicin, and the uptake of [F-18]FDG and [C-11]choline was measured. Anthracycline treatment decreased remarkably the [C-11]choline accumulation in a concentration dependent manner, while it did not modify significantly the [F-18]FDG uptake of the cells.

• 出版日期2009-10