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摘要
A special isophorone diisocyanate(IPDI) type polyurethane(PU) elastomer with good mechanical property was prepared. Heparin was grafted on the surface of this PU elastomer and a PU-Hep elastomer was obtained. The dynamic adsorption of bovine serum albumin (BSA) on PU elastomers was investigated by immersing the PU and PU-Hep elastomers in dilute BSA aqueous solution and measuring the viscosity change of the solution. The results show that BSA macromolecules quickly accumulate on the surface of PU and PU-Hep elastomers, however, it needs a long time to reach the adsorption equilibrium. The conformational chang of BSA macromolecules happens in bulk solution after adsorption on the PU and PU-Hep elastomers.
