A retrospective observational study to assess adverse transfusion reactions of patients with and without prior transfusion history

作者：Kato H^*; Nakayama T; Uruma M; Okuyama Y; Handa M; Tomiyama Y; Shimodaira S; Takamoto S

来源：Vox Sanguinis, 2015, 108(3): 243-250.

DOI：10.1111/vox.12208

• adverse transfusion reaction
• allergic reaction
• first transfusion
• haemovigilance
• transfusion episode

Background and ObjectivesThis study compares the frequency of adverse transfusion reactions (ATRs) after first transfusions with the frequency of ATRs for subsequent (non-first) transfusions.
Materials and MethodsFive hospitals agreed to systematically collect and share 2years of data. This was a retrospective observational analysis of data including the number of transfusion episodes and ATRs for red blood cells (RBCs), fresh frozen plasma (FFP) and platelet concentrates (PCs) given to first-time transfusion recipients and to those previously transfused.
ResultsFirst transfusion ATRs to RBCs, FFP and PCs were 108%, 284% and 334%, respectively. These are higher than ATR incidences to RBCs (069%), FFP (191%) and PCs (275%) on subsequent transfusions. Specifically, first transfusion incidences of febrile non-haemolytic transfusion reactions (FNHTRs) to RBCs (043%) and allergic reactions to FFP (251%) were higher than on subsequent transfusions (RBCs: 023%, FFP: 165%).
ConclusionThere are risks of ATRs on the first transfusion as well as transfusions of patients with transfusion history.

• 出版日期2015-4