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摘要
We disclose herein a highly enantioselective de novo-synthesis of chiral 1-cyclopentenyl-alpha-keto esters starting from a simple bis-silyl-1,3-dienediolate and alpha,beta-unsaturated aldehydes via a domino vinylogous Michael-intramolecular Knoevenagel-type condensation. The cyclopentenes proved to be highly versatile and were readily converted into various structural motifs.
- 出版日期2015
