Mitochondrial dynamics and Ca2+ signaling

作者：Szabadkai G; Simoni A M; Bianchi K; De Stefani D; Leo S; Wieckowski M R; Rizzuto R^*

来源：Biochimica et Biophysica Acta-Molecular Cell Research, 2006, 1763(5-6): 442-449.

DOI：10.1016/j.bbamer.2006.04.002

• mitochondria
• morphology
• Ca2+
• Drp-1
• GTPase
• cell death

Recent data shed light on two novel aspects of the mitochondria-Ca2+ liaison. First, it was extensively investigated how Ca2+ handling is controlled by mitochondrial shape, and positioning; a playground also of cell death and survival regulation. On the other hand, significant progress has been made to explore how intra- and near-mitochondrial Ca2+ signals modify mitochondrial morphology and cellular distribution. Here, we shortly summarize these advances and provide a model of Ca2+-mitochondria interactions.

• 出版日期2006-6