Accelerated long-term forgetting in temporal lobe epilepsy: Evidence of improvement after left temporal pole lobectomy

作者：Gallassi Roberto^*; Sambati Luisa; Poda Roberto; Maserati Michelangelo Stanzani; Oppi Federico; Giulioni Marco; Tinuper Paolo

来源：Epilepsy and Behavior, 2011, 22(4): 793-795.

DOI：10.1016/j.yebeh.2011.09.003

• Accelerated long-term forgetting
• Temporal lobe epilepsy
• Temporal pole lobectomy
• Neuropsychology
• Cognitive functions
• Memory
• Amnesia

Accelerated long term forgetting (ALF) is a characteristic cognitive aspect in patients affected by temporal lobe epilepsy that is probably due to an impairment of memory consolidation and retrieval caused by epileptic activity in hippocampal and parahippocampal regions. We describe a case of a patient with TLE who showed improvement in ALF and in remote memory impairment after an anterior left temporal pole lobectomy including the uncus and amygdala. Our findings confirm that impairment of hippocampal functioning leads to pathological ALF, whereas restoration of hippocampal functioning brings ALF to a level comparable to that of controls.

• 出版日期2011-12