Application of Folin-Ciocalteu reagent for the spectrophotometric determination of zolmitriptan in pharmaceutical preparations

作者：Ansari Tariq Mahmood; Raza Asad^*

来源：Journal of the Indian Chemical Society, 2013, 90(12): 2181-2186.

• Zolmitriptan
• Folin-Ciocalteu reagent
• pharmaceutical formulations
• spectrophotometry

A fast and selective spectrophotometric method for the determination of zolmitriptan in pharmaceutical bulk and dosage forms is described. The method is based on the formation of blue colored chromogen due to reduction of tungstate in Folin-Ciocalteu reagent by zolmitriptan in alkaline medium. The colored species has an absorption maximum at 750 nm and the Beer's law obeys over the concentration range of 3-50 mu g mL(-1). The limit of detection and quantification value is 3.43 and 11.33 mu g mL(-1) respectively. Application of the proposed method to bulk powder and commercial pharmaceutical tablets is also presented. No significant difference was obtained between the results of the proposed method and the official USP method. The procedure described in this paper is simple, rapid and extraction free.

• 出版日期2013-12