Apolipoprotein-E genotypes and myasthenia gravis

作者：Suhail Hamid; Soundararajan Christhunesa C; Vivekanandhan Subbiah; Singh Sumit; Behari Madhuri^*

来源：Neurology India, 2010, 58(3): 443-445.

DOI：10.4103/0028-3886.65533

• AChR
• Apolipoprotein-E
• autoimmunity
• myasthenia gravis
• genotype

Autoimmune myasthenia gravis (MG) is a disorder of neuromuscular junction. Possible role of multiple genes in the development of the MG has been documented. This case-control study, studied the association of apolipoprotein E (Apo-E) alleles with MG. Anti-AChR antibody was measured using radio receptor immunoassay. Apo-E genotypes were analyzed in 120 MG patients and 120 healthy subjects. Comparison between patients with MG and controls showed no significant association with Apo-E allelic variants. However, a significant association of Apo-E4 allele with AChR-antibody positive patients was observed (P = 0.007). Also, among seropositive patients, a significant association was seen between female gender and Apo-E4 allele (P = 0.023). Our results suggest that the presence of Apo-E4 allele might influence seropositive status in patients with MG and seems an associated susceptible factor in female patients.

• 出版日期2010-6
• 单位河北医科大学