Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression

作者：Ting Yuwen; Chang Wei-Tang; Shiau Duen-Kai; Chou Pei-Hsuan; Wu Mei-Fang; Hsu Chin-Lin^*

来源：Journal of Agricultural and Food Chemistry, 2018, 66(1): 70-80.

DOI：10.1021/acs.jafc.7b03551

• high-fat diet
• quercetin
• lycopene
• taurine
• litchi flower extract

The antiobesity effects of quercetin-rich supplement (QRS), which contain quercetin, lycopene, taurine, and litchi flower extract, on a high-fat diet (HFD)-induced obese rats were investigated. The rats that consume HFD with QRS (185 mg/kg rat) have significantly modulated the final body weights [490 +/- 11 (HFD) -> 441 +/- 11 (HFD+QRS) g], total body fat [112.9 +/- 4.5 (HFD) -> 86.6 +/- 5.7 (HFD+QRS) g], liver weights [14.8 +/- 0.4 (HFD) -> 12.6 +/- 0.4 (HFD+QRS) g/rat], and the serum TG [102.5 +/- 7.3 (HFD) -> 90.7 +/- 6.5 (HFD+QRS) mg/dL] to a level that resembled the regular diet-consumed rats (p < 0.05). The excretion of lipid in the faeces augmented in QRS groups as compared with the nonsupplemented HFD group [faecal total lipid: 62.43 +/- 2.80 (HFD) -> 73.15 +/- 0.88 (HFD+QRS) mg/g dried faeces, p < 0.05]. In the histological analysis, quercetin-rich formulation supplemented groups presented a much less lipid accumulation and smaller size of adipocytes. Moreover, a decreased serum thiobarbituric acid reactive substances [1.55 +/- 0.17 (HFD) -> 0.78 +/- 0.04 (HFD+QRS) nmol MDA eq/mL serum] increased levels of serum Trolox equivalent antioxidant capacity [3.89 +/- 0.08 (HFD) -> 6.46 +/- 0.20 (HFD+QRS) mu mol/mL serum], and more active hepatic antioxidant enzymes were observed in the supplemented groups (p < 0.05). The result of this work is a good demonstration of how a combination of bioactive compounds could work synergistically and become very effective in disease prevention.

• 出版日期2018-1-10