Anti-Inflammatory Effects of LK-3, on LPS-Induced Sepsis in Rats

作者：Tsai Wen Hui; Cheng Pao Yun; Lee Yen Mei; Chiu Min Chen; Jiau Shyi Shiaw; Wu Edwin S C; Yen Mao Hsiung^*

来源：Chinese Journal of Physiology, 2008, 51(5): 292-300.

• dextromethorphan
• reactive oxygen species
• sepsis
• TNF-alpha
• nitric oxide
• circulatory failure

Dextromethorphan (DM), an antitussive agent, has been shown to have anti-inflammatory and immunomodulatory effects in vitro. Thus, the aim of this study was to evaluate the effects of LK-3, an analog of DM, on sepsis induced by intravenous (i.v.) administration of lipopolysaccharide (LPS; 10 mg/kg) in anesthetized Wistar rats. Results demonstrated that post-treatment with LK-3 (4 mg/kg, i.v.) significantly attenuated the deleterious hemodynamic changes (e.g., hypotension and bradycardia) in rats treated with LPS. Meanwhile, LK-3 (4 mg/kg) significantly inhibited the elevation of plasma tumor necrosis factor-a, as well as values of glutamate-oxalacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) caused by LPS. The induction of inducible NO synthase and the overproduction of NO and superoxide anions by LPS were also reduced by post-treatment of LK-3. Moreover, infiltration of neutrophils into the lungs and liver of rats 8 h after treatment with LPS was also reduced by post-treatment with LK-3. In conclusion, the beneficial effects of LK-3 on LPS-induced sepsis resulted from its anti-inflammatory and antioxidant effects.

• 出版日期2008-10-31
• 单位中国医科大学