Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides

作者：Lin Wei Ling; Guu Shih Yun; Tsai Chan Chuan; Prakash Ekambaranellore; Viswaraman Mohan; Chen Hsing Bao; Chang Chuan Fa^*

来源：PLos One, 2015, 10(6): e0130389.

DOI：10.1371/journal.pone.0130389

Molecules derived from cinnamon have demonstrated diverse pharmacological activities against infectious pathogens, diabetes and inflammatory diseases. This study aims to evaluate the effect of the cinnamon-derived molecule IND02 on the adhesion of leukocytes to host cells. The anti-inflammatory ability of IND02, a pentameric procyanidin type A polyphenol polymer isolated from cinnamon alcohol extract, was examined. Pretreatment with IND02 significantly reduced the attachment of THP-1 cells or neutrophils to TNF-alpha-activated HUVECs or E-selectin/ICAM-1, respectively. IND02 also reduced the binding of E-, L- and P-selectins with sialosides. Furthermore, IND02 could agglutinate human red blood cells (RBC), and the agglutination could be disrupted by sialylated glycoprotein. Our findings demonstrate that IND02, a cinnamon-derived compound, can interact with sialosides and block the binding of selectins and leukocytes with sialic acids.

• 出版日期2015-6-15