High expression of Bcl-2 predicts poor outcome in diffuse large B-cell lymphoma patients with low international prognostic index receiving R-CHOP chemotherapy

作者：Choi Yong Won; Ahn Mi Sun; Choi Jin Hyuk; Lee Hyun Woo^*; Kang Seok Yun; Jeong Seong Hyun; Park Joon Seong; Han Jae Ho^*; Kim Jang Hee; Sheen Seung Soo

来源：International Journal of Hematology, 2016, 103(2): 210-218.

DOI：10.1007/s12185-015-1911-0

• Lymphoma
• Bcl-2
• Chemotherapy
• R-CHOP

The prognostic significance of Bcl-2, Bcl-6, p53, topoisomerase II, and beta-tubulin expression was evaluated in diffuse large B-cell lymphoma (DLBCL) patients treated with cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab. Eight-year progression-free survival (PFS, P = 0.006) and overall survival (OS, P = 0.001) of patients with high Bcl-2 expression were significantly inferior to those of patients with low expression without prognostic significance of Bcl-6, p53, topoisomerase II, and beta-tubulin expression. High expression of Bcl-2 was associated with poor PFS (P = 0.045) and OS (P = 0.004) only in patients with low international prognostic index (IPI). In multivariate analysis, high expression of Bcl-2 was a significant independent prognostic factor of poor PFS (P = 0.026) and OS (P = 0.007) along with high IPI. In conclusion, the expression of Bcl-2 may be a useful prognostic factor, especially in DLBCL patients with low IPI.

• 出版日期2016-2