Aging-Associated Changes in Physical Performance and Energy Metabolism in the Senescence-Accelerated Mouse

作者：Haramizu Satoshi; Ota Noriyasu; Hase Tadashi; Murase Takatoshi^*

来源：Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2011, 66(6): 646-655.

DOI：10.1093/gerona/glr037

• Aging
• Fatty acid oxidation
• Peroxisome proliferator-activated receptor-gamma-coactivator-1-Physical performance

The aim of the study was to clarify the aging-associated changes in physical performance and energy metabolism in senescence-accelerated prone mouse (SAMP1). The endurance of aged SAMP1 was significantly lower by 28% than the age-matched senescence-resistant mouse (SAMR1). Oxygen consumption and fat oxidation in aged SAMP1 were lower by 19% and 22%, respectively. Peroxisome proliferator activated receptor-gamma-coactivator-1 beta and medium-chain acyl coenzyme A dehydrogenase messenger RNA expression was significantly lower in aged SAMP1. Aged SAMP1 exhibited higher plasma glucose, insulin, leptin, and lower adiponectin concentrations. Aged SAMP1 also had higher malondialdehyde levels in plasma and tissues and lower peroxisome proliferator activated receptor-gamma messenger RNA and protein levels in adipose tissue. These results indicate that physical performance and energy expenditure decrease earlier with aging in SAMP1, accompanied by decreased fatty acid catabolism in muscle and liver and increased inflammation and oxidative stress in adipose tissue. SAMP1 could thus be a useful accelerated functional depression model for studying physical performance and energy metabolism.

• 出版日期2011-6