Associations of the 5-hydroxytryptamine (serotonin) Receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse

作者：Cao Jian; LaRocque Emily; Li Dawei^*

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2013, 162B(2): 169-176.

DOI：10.1002/ajmg.b.32128

• substance use disorder
• addiction
• meta-analysis
• association
• linkage disequilibrium

Abnormal serotonergic pathways are implicated in numerous neuropsychiatric disorders including alcohol and drug dependence (abuse). The human 5-hydroxytryptamine (serotonin) receptor 1B, encoded by the HTR1B (5-HT1B) gene, is a presynaptic serotonin autoreceptor that plays an important role in regulating serotonin synthesis and release. Although there was evidence of associations of the HTR1B gene variants in the etiologies of substance use disorders, negative findings were also reported. To clarify the roles of commonly reported single nucleotide polymorphisms (SNPs) of the HTR1B gene underlying alcohol and drug dependence (abuse), we performed a meta-analysis based on the available genotype data from individual candidate gene-based association studies. Evidence of association was found between the functional SNP 161A%26gt;T (rs130058) and alcohol, cocaine, and heroin dependence (e.g., P=0.03 and odds ratio (OR)=1.2 (1.02, 1.42) in the combined European, Asian, African, and Hispanic populations). SNP 261T%26gt;G (rs11568817) also showed evidence of association but with different directions in Europeans and non-Europeans (e.g., P=0.0018 with OR=1.42 (1.14, 1.76) and P=0.01 with ORs=0.5 (0.3, 0.85), respectively). This meta-analysis supports the associations of HTR1B 261T%26gt;G and 161A%26gt;T with alcohol and drug abuse and further investigations are warranted in larger samples.

• 出版日期2013-3