Association of General Fatigue With Cellular Immune Indicators Among Healthy White-Collar Employees

作者：Nakata Akinori^*; Irie Masahiro; Takahashi Masaya

来源：Journal of Occupational and Environmental Medicine, 2011, 53(9): 1078-1086.

DOI：10.1097/JOM.0b013e318229a938

Objective: Although fatigue is a common complaint in the working population, underlying immunological mechanisms are not well understood. This study investigated the association of general fatigue with cellular immune indicators. Methods: A total of 148 healthy white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), B, and T cell counts as well as NK cell cytotoxicity (NKCC) and completed two different fatigue scales, that is, Profile of Mood State (POMS) and Maastricht Questionnaire (MQ). Results: Multiple linear regression analyses revealed that POMS fatigue score was significantly associated with decreases of NK cells (beta = -.407) and NKCC (beta = -.215), whereas MQ fatigue score was significantly associated with reduced NK cells (beta = -.290) but not with NKCC (beta = -.127). Conclusion: The results suggest that general fatigue may be related to impaired NK cell competency among healthy employees.

• 出版日期2011-9