Acantholactone, a new manzamine related alkaloid with an unprecedented delta-lactone and epsilon-lactam ring system

作者：Wahba Amir E; Fromentin Yann; Zou Yike; Hamann Mark T^*

来源：Tetrahedron Letters, 2012, 53(47): 6329-6331.

DOI：10.1016/j.tetlet.2012.08.140

• Manzamine alkaloids

A new manzamine-related alkaloid with unprecedented S-lactone and e-lactam rings called acantholactone (2), was isolated from the Indonesian sponge Acanthostrongylophora sp. The relative configuration of the two new ring systems was established through detailed analysis of NOESY correlations combined with molecular modeling studies. The absolute configuration of 2 was determined as 12S, 24R, 25R, 26R by comparing the computed electronic circular dichroism (ECD) spectra with experimental values. Published by Elsevier Ltd.

• 出版日期2012-11-21