Association between CAG repeat length in the PPP2R2B gene and Alzheimer disease in the Japanese population

作者：Kimura Ryo^*; Morihara Takashi; Kudo Takashi; Kamino Kouzin; Takeda Masatoshi

来源：Neuroscience Letters, 2011, 487(3): 354-357.

DOI：10.1016/j.neulet.2010.10.055

• Alzheimer disease
• CAG repeat
• PPP2R2B

We analyzed the association between PPP2R2B gene CAG repeat length and Alzheimer disease (AD) susceptibility in the Japanese population. Blood samples were collected from 218 late-onset AD patients and 86 controls. DNA fragments containing the target GAG repeat region were amplified using polymerase chain reaction (PCR). PCR products were sequenced using ABI PRISM 310 genetic analyzer. The mean CAG repeat length did not differ significantly between the control and AD groups. In contrast, the frequency of CAG repeats shorter than 15 was significantly higher in AD group, specifically in the AD with APOE4 subgroup, than in the control group. The results suggest that CAG repeat lengths in the PPP2R2B gene may be potential genetic markers for AD susceptibility in the Japanese population.

• 出版日期2011-1-10