H1N1 pandemic: clinical and epidemiologic characteristics of the Canadian pediatric outbreak

作者：Flechelles Olivier; Fowler Robert; Jouvet Philippe^*

来源：Expert Review of Anti-Infective Therapy, 2013, 11(6): 555-563.

DOI：10.1586/ERI.13.40

• Aboriginal people
• antiviral therapy
• asthma
• Canada
• children
• clinical manifestations
• H1N1 pandemic
• social distancing measures
• vaccination

Canada was one of the first countries affected by the 2009 influenza H1N1 pandemic with two waves - one from May to June and one from October to December. The 2009 influenza H1N1 pandemic had many unique features when compared with seasonal influenza, including the following: more than half of the affected people were children; asthma was the most significant risk factor for hospital admission; and Aboriginal and pregnant women had a higher risk of hospital admission and complications. Antiviral therapy was widely used but data did not show any effect on the pediatric population. Outbreak spread was possibly promoted from child-child and child-adult contact, and therefore the vaccination campaign targeted the pediatric population and achieved good coverage among young children (57%). Vaccination efficacy was difficult to test because of the vaccination delay. Improvement in models of prevention and treatment are urgently needed to prepare for the possible future pandemics.

• 出版日期2013-6