An efficient method for the synthesis of alpha-arylated nitroalkanes and alpha-arylated hydroximoyl chlorides mediated by AlCl3

作者：Tu Zhijay; Raju B Rama; Liou Tzuo Rung; Kavala Veerababurao; Kuo Chun Wei; Jang Yaochung; Shih Yu Hsuan; Wang Chun Chao; Yao Ching Fa^*

来源：Tetrahedron, 2009, 65(12): 2436-2442.

DOI：10.1016/j.tet.2009.01.075

Friedel-Crafts alkylation of various arenes/heteroarenes to beta-nitrostyrenes mediated by aluminum chloride is described. The interesting feature of this methodology pertain the formation of different products by tuning the reaction temperature. alpha-Arylated nitroalkanes were formed predominately at -78 degrees C, whereas alpha-arylated hydroximoyl chlorides were obtained at room temperature without any side products in high yields.

• 出版日期2009-3-21