Arterial Stiffness Is Inversely Related to Plasma Adiponectin Levels in Young Normotensive Patients With Type 1 Diabetes

作者：Tsiakou Afroditi^*; Liatis Stavros; Alexiadou Kleopatra; Diakoumopoulou Evanthia; Makrilakis Konstantinos; Tentolouris Nicholas; Kyriaki Despoina; Katsilambros Nicholas

来源：Diabetes Care, 2013, 36(3): 734-736.

DOI：10.2337/dc12-0387

OBJECTIVE-This study investigated the association between arterial stiffness and plasma adiponectin in patients with type 1 diabetes. %26lt;br%26gt;RESEARCH DESIGN AND METHODS-Participants were normotensive patients with type 1 diabetes who were up to age 40 years. Subjects on statins with macrovascular disease or overt nephropathy were excluded. Large artery stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV), whereas plasma adiponectin was measured by radioimmunoassay. %26lt;br%26gt;RESULTS-Data from 80 patients (age 27.1 +/- 6.1 years, BMI 24.2 +/- 3.1 kg/m(2), HbA(1c) 7.5 +/- 1.6%, 39 men, adiponectin 13.9 +/- 6.7 mu g/mL, and PWV 5.6 +/- 0.9 m/s) were analyzed. Log adiponectin inversely correlated with age-adjusted PWV (r = -0.291, P = 0.009) and waist circumference (r = -0.427, P %26lt; 0.001). In a fully adjusted model, age, expiration/inspiration index, and log adiponectin were independently associated with PWV, explaining 39.6% of its variance. %26lt;br%26gt;CONCLUSIONS-Arterial stiffness is inversely related to adiponectin concentration in young patients with type 1 diabetes without major complications. Diabetes Care 36:734-736, 2013

• 出版日期2013-3