Are the Same Clinical Risk Factors Relevant for Incident Diabetes Defined by Treatment, Fasting Plasma Glucose, and HbA(1c)?

作者：Balkau Beverley^*; Soulimane Soraya; Lange Celine; Gautier Alain; Tichet Jean; Vol Sylviane

来源：Diabetes Care, 2011, 34(4): 957-959.

DOI：10.2337/dc10-1581

OBJECTIVE-To compare incidences and risk factors for diabetes using seven definitions, with combinations of pharmacological treatment, fasting plasma glucose (FPG) >= 7.0 mmol/L, and HbA(1c) >= 6.5%.
RESEARCH DESIGN AND METHODS-Participants aged 30-65 years from the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort were followed for 9 years.
RESULTS-More men had incident diabetes as defined by FPG mmol/L and/or treatment than by HbA(1c) >= 6.5% and/or treatment: 7.5% (140/1,867) and 5.3% (99/1,874), respectively (P < 0.009); for women incidences were similar: 3.2% (63/1,958) and 3.4% (66/1,954). Known risk factors predicted diabetes for almost all definitions. Among those with incident diabetes by FPG alone versus HbA(1c) alone, there were more men (78 vs. 35%), case patterns were 8 years younger, and fewer were alcohol abstainers (12 vs. 35%) (all P < 0.005). A diabetes risk score discriminated well between those with and without incident diabetes for all definitions.
CONCLUSIONS-In men, FPG definitions yielded more incident cases of diabetes than HbA(1c) definitions, in contrast with women. An FPG-derived risk score remained relevant for HbA(1c)-defined diabetes.

• 出版日期2011-4