Testosterone decrease does not play a major role in the suppression of hippocampal cell proliferation following social defeat stress in rats

作者：Buwalda Bauke^*; van der Borght Karin; Koolhaas Jaap M; McEwen Bruce S

来源：Physiology & Behavior, 2010, 101(5): 719-725.

DOI：10.1016/j.physbeh.2010.08.010

• Testosterone supplementation
• Proliferation
• Survival
• Resident intruder
• Corticosterone
• Social stress

Stress of social defeat in rodents is known to have a strong and long-lasting effect on brain physiology and behavior which bears similarities with certain human stress related psychopathologies Previous experiments in this lab showed that social defeat stress suppresses testosterone secretion and causes a lasting desensitization of the serotonergic 5-HT(1A) receptors Testosterone supplementation in socially stressed tree shrews prevented a decrease in hippocampal 5-HT(1A) receptor binding These receptors are hypothesized to play an important role in neurogenesis in this brain structure We designed the present experiment to test if social defeat reduces hippocampal cell proliferation and neurogenesis in rats and if testosterone supplementation can prevent this reduction The results indicate that repeated social defeat stress on 5 successive days Induces a significant drop in plasma testosterone levels in male rats and suppresses hippocampal cell proliferation 24 h and 3 weeks after the end of the stress period Testosterone supplementation prevented the social stress induced drop in plasma testosterone levels The hormone supplementation also reduced the negative effect of stress on hippocampal BrdU labeling at 3 weeks post-defeat This effect was however rather weak and was caused by the tendency of the hormone in itself to suppress proliferation and the failure to fully recover the proliferation rate Survival of dentate gyrus cells that either proliferated prior to the stress period or 24 h after the last defeat was not affected by the social defeats Thus t

• 出版日期2010-12-2