Secondary myelofibrosis in children

作者:Naithani Rahul*; Tvagi Seenia; Choudhry Ved Prakash
来源:Journal of Pediatric Hematology/Oncology, 2008, 30(3): 196-198.

摘要

Myelofibrosis is a rare childhood myeloproliferative disorder. It has been reported as an associated complication of certain hematologic malignancies or as an isolated idiopathic process. We describe clinical course of 6 children diagnosed over 6 years. One child each responded well to steroid and treatment of the underlying condition. Three children died because of underlying conditions and I child was lost to follow up. A thorough search should be made for underlying disease when myelofibrosis is first diagnosed. Trephine biopsy though giving useful information, does not have a prognostic significance.