Post-synthetic modification of tryptophan containing peptides via NIS mediation

作者：Gu, Chen-Xue; Bi, Qing-Wei; Gao, Chu-Kun; Wen, Jian; Zhao, Zhi-Gang^*; Chen, Zili^*

来源：Organic and Biomolecular Chemistry, 2017, 15(16): 3396-3400.

DOI：10.1039/c7ob00329c

• C-H ACTIVATION
• RHODIUM CARBENOIDS
• BOND FORMATION
• AMINO-ACIDS
• ARYLATION
• DIVERSIFICATION
• RESIDUES
• INDOLE
• 1,2,3-TRIAZOLES
• MILD

A new efficient method was developed to provide modified tryptophan peptides through NIS (N-iodosuccinimide) mediated N-2-selective coupling of a Trp unit with 1,2,3-triazoles, of which, the preliminary spectral properties were also studied.

• 出版日期2017-4-28
• 单位西南民族大学; 中国人民大学