Multicentric human papillomavirus-associated head and neck squamous cell carcinoma

作者：Caley Andrew; Evans Mererid; Powell Ned; Paleri Vinidh; Tomkinson Alun; Urbano Teresa Guerrero; Jay Amrita; Robinson Max; Thavaraj Selvam^*

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2015, 37(2): 202-208.

DOI：10.1002/hed.23584

• second primary tumor
• human papillomavirus
• head and neck squamous cell carcinoma
• multicentric
• pharyngeal

BackgroundThe purpose of this study was to present the clinicopathological features of a series of patients with human papillomavirus (HPV)-associated head and neck second primary tumors.
MethodsPatients with HPV-associated head and neck second primary tumors from 3 centers were identified. HPV infection was evaluated using p16 by immunohistochemistry (IHC), high-risk HPV DNA by in situ hybridization (ISH), and HPV genotyping by DNA polymerase chain reaction (PCR) enzyme immunoassay (EIA).
ResultsEleven patients were identified: 5 with synchronous and 6 with metachronous HPV-positive second primary tumors, the latter demonstrating a mean time interval of 5 years. There were 13 second primary tumors: 11 oropharyngeal, 1 nasopharyngeal, and 1 floor of the mouth. Nine of 10 genotyped patients harbored HPV-16, and 1 patient had HPV-33 in 3 synchronous tumors.
ConclusionHPV-associated second primary tumors may present as synchronous and/or metachronous lesions and can arise outside the oropharynx after prolonged intervals. Further work is necessary to identify patients at risk and to elucidate the mechanisms of HPV-associated head and neck second primary tumors.

• 出版日期2015-2