Diastereoselective Synthesis of the Aminocyclitol Core of Jogyamycin via an Allene Aziridination Strategy

作者：Gerstner Nels C; Adams Christopher S; Grigg R David; Tretbar Maik; Rigoli Jared W; Schomaker Jennifer M^*

来源：Organic Letters, 2016, 18(2): 284-287.

DOI：10.1021/acs.orglett.5b03453

Oxidative allene amination provides rapid access to densely functionalized amine-containing stereotriads through highly reactive bicyclic methyleneaziridine intermediates. This strategy has been demonstrated as a viable approach for the construction of the densely functionalized aminocyclitol core of jogyamycin, a natural product with potent antiprotozoal activity. Importantly, the flexibility of oxidative allene amination will enable the syntheses of modified aminocyclitol analogues of the jogyamycin core.

• 出版日期2016-1-15