Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep

作者：Dean Justin M; van de Looij Yohan; Sizonenko Stephane V; Lodygensky Gregory A; Lazeyras Francois; Bolouri Hayde; Kjellmer Ingemar; Huppi Petra S; Hagberg Henrik; Mallard Carina^*

来源：Annals of Neurology, 2011, 70(5): 846-856.

DOI：10.1002/ana.22480

Objective: Preterm infants exhibit chronic deficits in white matter (WM) and cortical maturation. Although fetal infection/inflammation may contribute to WM pathology, the factors contributing to cortical changes are largely unknown. We examined the effect of fetal lipopolysaccharide (LPS) exposure on WM and cortical development as assessed by magnetic resonance imaging (MRI), electroencephalography (EEG), and histopathology in fetal sheep at preterm human equivalent age.

• 出版日期2011-11