Aminocatalyzed asymmetric Diels-Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives

作者：Zhu, Kailong; Huang, Huicai; Wu, Wenbin; Wei, Yuan; Ye, Jinxing^*

来源：Chemical communications, 2013, 49(21): 2157-2159.

DOI：10.1039/c3cc00023k

• UDP-GALACTOPYRANOSE MUTASE
• TRIENAMINE CATALYSIS
• MEDICINAL CHEMISTRY
• IDENTIFICATION
• CONSTRUCTION
• ACTIVATION
• INHIBITORS
• DISCOVERY

Aminocatalyzed asymmetric Diels-Alder reaction between 2,4-dienals and rhodanine/hydantoin derivatives via trienamine mechanism has been developed to synthesize various spirocyclic compounds with good yields (up to 98%) and excellent stereoselectivities (up to 99% ee and >19 : 1 dr).

• 出版日期2013
• 单位华东理工大学