Autoimmunity arising from bystander proliferation of T cells in an immune response model

作者：Burroughs N J; Ferreira M^*; Oliveira B M P M; Pinto A A

来源：Mathematical and Computer Modelling, 2011, 53(7-8): 1389-1393.

DOI：10.1016/j.mcm.2010.01.020

• Immunology
• T cells
• Tregs
• Cytokines
• Bystander proliferation
• ODE model

We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period.

• 出版日期2011-4