Determinants of IGF1 and GH across the weight spectrum: from anorexia nervosa to obesity

作者：Brick D J; Gerweck A V; Meenaghan E; Lawson E A; Misra M; Fazeli P; Johnson W; Klibanski A; Miller K K^*

来源：European Journal of Endocrinology, 2010, 163(2): 185-191.

DOI：10.1530/EJE-10-0365

Context: Chronic starvation is characterized by GH resistance, and obesity is characterized by decreased GH secretion. In both extremes, IGF1 levels may be low and androgen levels may be abnormal.
Objective: To investigate the determinants of IGF1 and GH across the weight spectrum in women.
Design: Cross-sectional study.
Setting: Clinical research center.
Study participants: In total, 32 women had participated in the study: 11 women with anorexia nervosa (AN), 11 normal-weight women, and 10 obese women of comparable mean age.
Intervention: None.
Main outcome measures: Pooled hourly overnight serum samples assayed for IGF1, GH, estradiol (E-2), testosterone, SHBG, insulin, free fatty acids, and trunk fat.
Results: Free testosterone was higher in obese women and lower in women with AN than in normal-weight women, and was the only independent (and positive) predictor of IGF1 levels, accounting for 14% of the variability (P=0.032) in the group as a whole. This relationship was stronger when obese women were excluded, with free testosterone accounting for 36% of the variability (P=0.003). Trunk fat accounted for 49% of the variability (P<0.0001) of GH, with an additional 7% of the variability attributable to E-2 (P=0.042) in the group as a whole, but was not a significant determinant of GH secretion when obese women were excluded.
Conclusions: Free testosterone is a significant determinant of IGF1 levels in women across the body weight spectrum. In contrast, GH secretion is differentially regulated at the extremes of the weight spectrum.

• 出版日期2010-8