Association between endotoxemia and histological features of nonalcoholic fatty liver disease

作者：Kitabatake Hiroyuki; Tanaka Naoki; Fujimori Naoyuki; Komatsu Michiharu; Okubo Ayaka; Kakegawa Kyogo; Kimura Takefumi; Sugiura Ayumi; Yamazaki Tomoo; Shibata Soichiro; Ichikawa Yuki; Joshita Satoru; Umemura Takeji; Matsumoto Akihiro; Koinuma Masayoshi; Sano Kenji; Aoyama Toshifumi; Tanaka Eiji

来源：World Journal of Gastroenterology, 2017, 23(4): 712-722.

DOI：10.3748/wjg.v23.i4.712

• Nonalcoholic steatohepatitis
• Endotoxemia
• Lipopolysaccharide-binding protein
• EndoCab IgG
• Fibrosis
• Steatosis

AIM
To assess whether surrogate biomarkers of endotoxemia were correlated with the histological features of
METHODS
One hundred twenty-six NAFLD patients who had undergone percutaneous liver biopsy were enrolled. Serum lipopolysaccharide (LPS)-binding protein (LBP) and anti-endotoxin core immunoglobulin G (EndoCab IgG) antibody concentrations at the time of liver biopsy were measured using the enzyme-linked immunosorbent assays to examine for relationships between biomarker levels and histological scores.
RESULTS
Serum LBP concentration was significantly increased in nonalcoholic steatohepatitis (NASH) patients as compared with nonalcoholic fatty liver (NAFL) subjects and was correlated with steatosis (r = 0.38, P < 0.0001) and ballooning scores (r = 0.23, P = 0.01), but not with the severity of lobular inflammation or fibrosis. Multivariate linear regression analysis revealed that LBP was associated with steatosis score and circulating C-reactive protein, aspartate aminotransferase, and fibrinogen levels. Serum EndoCab IgG concentration was comparable between NASH and NAFL patients. No meaningful correlations were detected between EndoCab IgG and histological findings.
CONCLUSION
LBP/EndoCab IgG were not correlated with lobular inflammation or fibrosis. More accurate LPS biomarkers are required to stringently assess the contribution of endotoxemia to conventional NASH.

• 出版日期2017-1-28